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Menu Logo Principal AgroParisTech Université Paris-Saclay

Genetique Animale et Biologie Integrative

Unité Mixte de Recherche INRA AgroParisTech GABI Génétique Animale et Biologie Intégrative

Didier BOICHARD, Directeur de Recherche

BOICHARD Didier
Evaluation des reproducteurs et sélection génomique ; amélioration génétique des bovins ; cartographie de QTL ; composition du lait ; anomalies génétiques

 

INRA, UMR 1313 Génétique Animale et Biologie Intégrative
Domaine de Vilvert, Bat 211, 78352 Jouy en Josas
Tel : +33 (0) 1 34 65 21 81 

Email : didier.boichard(at)inra.fr

Équipe Génétique et Génomique Bovine

 CV :

  • Ingénieur agronome de l’Institut National Agronomique Paris Grignon, 1982
  • DEA de Génétique quantitative, Paris VI, 1985
  • Thèse de docteur ingénieur de l’INA Paris Grignon, 1987
  • Chargé de recherche INRA (1987) puis Directeur de Recherche (1996)
  • Directeur du Département de Génétique Animale de 2002 à 2009
  • Président du GIE Labogena de 2004 à 2013
  • Membre de l'Académie Vétérinaire de France
  • L'équipe G2B a reçu le Laurier de l'Impact de l'INRA en 2016, pour son activité de sélection génomique bovine

Domaines de recherche : 

Sélection génomique ; amélioration génétique des bovins ; génétique quantitative ; évaluation génétique des reproducteurs ; cartographie de QTL ; déterminisme génétique de la composition du lait ; déterminisme génétique de la fertilité ; déterminisme génétique de la résistance aux mammites ;  gènes à effets majeurs et anomalies génétiques.

Autres activités :

  • Coordination : animateur de l’équipe G2B, coanimateur de l'UMT 3G (2011-16) puis de l'UMT eBIS
  • Expertise : Membre de la Commission Nationale d’Amélioration Génétique ; membre du comité de direction de France Génétique Elevage
  • Edition : co-rédacteur en chef de Genetics Selection Evolution

Publications récentes :

Mesbah-Uddin M., Guldbrandtsen B., Iso-Touru T., Vilkki J., De Koning D.J., Boichard D., Lund M.S., Sahana G. 2017. Genome-wide mapping of large deletions and their population-genetic properties in dairy cattle. DNA Research, ehead of print, doi: 10.1093/dnares/dsx037.

Sanchez M.P., Govignon-Gion A., Croiseau P., Fritz S., Hoze C., Miranda G., Martin P., Barbat-Leterrier A., Brochard M., Boussaha M., Boichard D. 2017. Within-breed and multi-breed GWAS on imputed whole genome sequence variants reveal candidate mutations affecting milk protein composition in dairy cattle. Genetics Selection Evolution, 49: 68.

Bourneuf E., Otz P., Pausch H., Jagannathan V., Michot P., Grohs C., Piton G., Ammermüller S., Deloche M.C., Fritz S., Leclerc H., Péchoux C., Boukadiri A., Saintilan R., Créchet F., Mosca M., Segelke D., Guillaume F., Bouet S., Baur A., Vasilescu A., Genestout L., Thomas A., Allais-Bonnet A., Rocha D., Colle M.A., Klopp C., Esquerré D., Wurmser C., Flisikowski K., Schwarzenbacher H., Burgstaller J., Brügmann M., Dietschi E., Huth N., Freick M., Barbey S., Fayolle G., Danchin-Burge C., Schibler L., Bed’hom B., Hayes B.J., Daetwyler H.D., Fries R., Boichard D., Pin D., Drögemüller C., Capitan A. 2016. Rapid Discovery of De Novo Deleterious Mutations in Cattle Using Genome Sequence Data: Enhancing the Value of Farm Animals as Model Species. Scientific Reports, 7: 11466.

Michot P., Fritz S., Barbat A., Boussaha M., Deloche M.C., Grohs C., Hoze C., Le Berre L., Le Bourhis D., Desnoes O., Salvetti P., Schibler L., Boichard D., Capitan A. A missense mutation in PFAS is likely causal for embryonic lethality associated with the MH1 haplotype in Montbeliarde dairy cattle. J Dairy Sci, 100, 8176–8187.

Duchesne A., Vaiman A., Castille J., Beauvallet C., Gaignard P., Floriot S., Rodriguez S., Vilotte M., Boulanger L., Passet B., Albaric O., Guillaume F., Boukadiri A., Richard L., Bertaud M., Timsit E., Guatteo R., Jaffrézic F., Calvel P., Mahla R., Esquerré D., Péchoux C., Liu S., Vallat J.M., Boichard D., Slama A., Vilotte J.L. 2017. Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health. Plos Genet., 13, e1006597.

Fang Z.H., Bovenhuis H., Delacroix-Buchet A., Miranda G., Boichard D., Visker M.H.P.W., Martin P. 2017. Genetic and non-genetic factors contributing to differences in alpha-s-casein phosphorylation isoforms and other major milk proteins. J Dairy Sci., 100, 5564-5577.

Sanchez M.P., Govignon-Gion A., Ferrand M., Gele M., Pourchet D., Miranda G., Martin P., Brochard M., Boichard D. 2017. Short-communication: Genetic parameters for milk protein composition in the French Montbéliarde, Normande and Holstein dairy cattle breeds. Journal of Dairy Science, 100, 6371-6375.

Boichard D. , Grohs C. , Danchin C., Capitan A. 2016. Anomalies génétiques : définition, principes et concepts. INRA Productions Animales, 29, 297-306.

Grohs C., Duchesne A., Floriot S., Deloche M.C., Boichard D., Ducos A., Danchin C. 2016. L’Observatoire National des Anomalies Bovines. INRA Productions Animales, 29, 307-318.

Duchesne A, Grohs C, Michot P, Boichard D, Floriot S, Fritz S., Capitan A. 2016. Du phénotype à la mutation causale d’anomalies récessives. INRA Productions Animales, 29, 319-328.

Fritz S.,  Michot P, Hoze C., Grohs C, Barbat A., Boussaha M., Boichard D, Capitan A. 2016. Fouille de données pour identifier des anomalies récessives. INRA Productions Animales, 29, 339-350.

Boichard D, Grohs C, Michot P, Danchin C, Capitan A, Genestout L, Barbier S., Fritz S. 2016. Prise en compte des anomalies génétiques en sélection. INRA Productions Animales, 29, 351-358.

Boussaha M., Michot P., Letaief R., Hoze C., Fritz S., Grohs C., Esquerre D., Duchesne A., Philippe R., Blanquet V., Phocas F., Floriot S., Rocha D., Klopp C., Capitan A., Boichard D. 2016. Construction of a large collection of small genome variations in French dairy and beef breeds using whole genome sequences. Genetics Selection Evolution, 48, 87.

Kadri N.K., Harland C., Faux P., Cambisano N., Karim L., Coppieters W., Fritz S., Mullaart E., Baurain D., Boichard D., Spelman R., Charlier C., Georges M., Druet T. Sequence-based association analysis identifies coding and non coding variants in HFM1, MLH3, MSH4, MSH5, RNF212 and RNF212B with large effects on male and female recombination rate in cattle. Genome Research, 26, 1323-1332.

Van Den Berg I., Boichard D., Lund M.S. 2016. Sequence variants selected from a multi breed GWAS can improve the reliability of genomic prediction in dairy cattle. Genetics Selection Evolution, 48, 83.

Van Den Berg I., Boichard D., Lund M.S. 2016. Comparing power and precision of within and multi breed genome wide association studies of production traits using whole genome sequence data for five French and Danish dairy cattle breeds. Journal of Dairy Science, 99, 8932–8945.

Van Den Berg  I., Boichard D., Guldbrandtsen B., Lund M.S. 2016. Use of sequence variants to improve accuracy of genomic prediction in dairy cattle breeds. G3, 6, 2553-2561.

Michot P., Chahory S., Marete A., Grohs C., Dagios D., Donzel E., Aboukadiri A., Deloche M.C., Allais-Bonnet A., Chambrial M., Barbey S., Boussaha M., Danchin-Burge C., Fritz S., Boichard D., Capitan A. 2016. A reverse genetic approach identifies an ancient frameshift mutation in RP1 causing recessive progressive retinal degeneration in European cattle breeds. Genetics Selection Evolution, 48, 56.

Sanchez M.P. , Govignon-Gion A., Ferrand M., Gele M., Pourchet D., Amigues Y., Fritz S., Boussaha M., Capitan A., Rocha D., Miranda G., Martin P., Brochard M., Boichard D. 2016. Whole genome scan to detect SNP associated to milk protein composition in three French dairy cattle breeds. Journal of Dairy Science, 99, 8203–8215

Colleau J. J., Fritz S., Guillaume F., Baur A., Dupassieux D., Boscher M.Y., Journaux L., Eggen A., Boichard D. 2015. Simulation des potentialités de la sélection génomique chez les bovins laitiers. INRA Productions Animales, 28, 251-258.

Boussaha M., Esquerre D., Barbieri J., Djari A., Pinton A., Letaief R., Salin G., Escudie F., Roulet A., Fritz S., Samson F., Grohs C., Bernard M., Klopp C., Boichard D., Rocha D. 2015. Genome-wide study of structural variants in bovine Holstein, Montbeliarde and Normande dairy breeds. Plos One, 10: e0135931.

Dezetter C., Leclerc H., Mattalia S., Barbat A., Boichard D., Ducrocq V. 2015. Inbreeding and Crossbreeding Parameters for Production and Fertility Traits in Holstein, Montbéliarde, and Normande Cows. Journal of Dairy Science, 98, 4904–4913.

Brøndum R.F, Su G., Janss L., Sahana G., Guldbrandtsen B., Boichard D., Lund M.S. 2015. QTL markers derived from whole genome sequence data increases the reliability of genomic prediction. J Dairy Sci., 98, 4107-4116.

Floriot S., Vesque C., Rodriguez S., Bourgain-Guglielmetti F., Karaiskou A., Gautier M., Duchesne A., Barbey S., Fritz S., Vasilescu A., Bertaud M., Moudjou M., Halliez S., Cormier-Daire V., El Hokayem J., Nigg E.A., Manciaux L., Guatteo R., Cesbron N., Toutirais G., Eggen A., Schneider-Maunoury S., Boichard D., Sobczak-Thépot J., Schibler L.  2015. C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle. Nature Communications, 6, 6894.

Michot P., Fantini O., Braques R., Allais-Bonnet A., Saintilan R., Grohs C., Barbieri J., Genestout L., Danchin C., Gourreau J.M., Boichard D., Pin D., Capitan A. 2015. Whole-genome sequencing identifies a homozygous deletion encompassing exons 17 to 22 of the Integrin Beta 4 Gene in a Charolais calf with Junctional Epidermolysis Bullosa. Genetics Selection Evolution, 47, 37.

Baumung R., Farkas J., Boichard D., Meszaros G., Sölkner J., Curik I. 2015. GRAIN: a computer program to calculate ancestral and partial inbreeding coefficients using a gene dropping approach. Journal of Animal Breeding and Genetics, 132, 100-108.

Boichard D., Ducrocq V., Fritz S. 2015. Sustainable dairy cattle selection in the genomic era. Journal of Animal Breeding and Genetics, 132, 135-143.

Capitan A., Michot P., Baur A., Saintilan R., Hoze C., Valour D., Guillaume F., Boichon D., Barbat A., Boichard D., Schibler L., Fritz S. 2015. Genetic tools to improve reproduction traits in dairy cattle. Reprod. Fert. Dev, 27, 14-21

Boichard D. 2014. Quel futur pour l’amélioration génétique chez les espèces domestiques ? Bulletin de l’Académie Vétérinaire de France,167, 103-108.

Boichard D., Govignon-Gion A., Larroque H., Maroteau C., Palhiere I., Tosser-Klopp G., Rupp R., Sanchez M.P., Brochard M. 2014. Déterminisme génétique de la composition en acides gras et protéines du lait des ruminants. INRA Productions Animales, 27, 283-298.

Daetwyler H.D., Capitan A., Pausch H., Stothard P.,  Van Binsbergen R., Brøndum R.F., Liao X., Djari A., Rodriguez S.C., Grohs C., Esquerré D., Bouchez O., Rossignol M.N., Klopp C., Rocha D., Fritz S., Eggen A., Bowman P., Coote D., Chamberlain A.J., Anderson C., Van Tassell C.P., Hulsegge I., Goddard M.E., Guldbrandtsen B., Lund M.S., Veerkamp R.F., Boichard D., Fries R.,  Hayes B.J. 2014. Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle. Nature Genetics, 46, 858-867.

Hozé C., Fritz S., Phocas F., Boichard D., Ducrocq V., Croiseau P. 2014. Efficiency of multi-breed genomic selection for dairy cattle breeds with different sizes of reference population. Journal of Dairy Science 97, 3918-3929.

Labatut J., Astruc J.M., Barillet F., Boichard D., Ducrocq V., Griffon L., Lagriffoul G. 2014. Implications organisationnelles de la sélection génomique: analyses et accompagnement. INRA Productions Animales, 27, 303-316.

Rocha D., Billerey C., Boichard D., Boussaha M. 2014. Identification of the putative ancestral allele of bovine single nucleotide polymormphisms. Journal of Animal Breeding and Genetics, 131, 483-486.

Van Den Berg I., Fritz I., Rodriguez S., Rocha D., Boussaha M., Lund M.S., Boichard D. 2014. Concordance analysis for QTL detection in dairy cattle: a case study of leg morphology. Genetics Selection Evolution, 46, 31.

Allais-Bonnet A., Grohs C., Medugorac I., Krebs S., Djari A., Graf A., Fritz S., Seichter D., Baur A., Bouet S., Wahlberg P., Esquerre D., Hoze C., Boussaha M., Weiss B., Thepot D., Venot E., Fouilloux M.N., Rossignol M.N., Van Marle-Köster E., Hreiðarsdottir G.E., Barbey S., Dozias D., Cobo E., Reverse P., Catros O., Marchand J.L., Soulas P., Roy P., Marquant-Leguienne B., Lebourhis D., Pannetier M., Phocas F., Klopp C.,  Rocha D., Fouchet M., Journaux L., Bernard-Capel C., Eggen A., Förster M., Gallard Y., Boichard D., Pailhoux E., Capitan A. 2013. Novel insights into the bovine polled phenotype and horn ontogenesis in Bovidae. Plos One 8, e63512.

Boichard D., 2013. La sélection génomique : une opportunité pour l’amélioration de la santé des animaux d’élevage. Bulletin de l’Académie Vétérinaire de France, 166, 25-31.

Brochard M., Boichard D., Ducrocq V., Fritz S. 2013. La sélection pour des vaches et une production laitière plus durables : acquis de la génétique et opportunités offertes par la sélection génomique. INRA Prod. Anim., 26, 139-150.

Fritz S., Capitan A., Djari A., Rodriguez S.C., Barbat A., Baur A., Grohs C., Weiss B., Boussaha M., Esquerre D., Klopp C., Rocha D., Boichard D. 2013. Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG, and SLC37A2. Plos One, 8, e65550.

Hoze C., Fouilloux M.N., Venot E., Guillaume F., Dassonneville R., Fritz S., Ducrocq V., Phocas F., Boichard D., Croiseau P. 2013. High density marker imputation efficiency in 16 French cattle breeds. Genet. Sel. Evol, 45, 33.

Van Den Berg I., Fritz S., Boichard D. 2013. QTL fine mapping with Bayesian C(π): a simulation study. Genet. Sel Evol., 45, 19.

Boichard D., Brochard M. 2012.  New phenotypes for new breeding goals in dairy cattle. Animal, 6, 544-550.

Boichard D., Guillaume F., Baur A., Croiseau P., Rossignol M.N., Boscher M.Y., Druet T., Genestout L., Colleau J.J., Journaux L., Ducrocq V., Fritz S. 2012. Genomic Selection in French Dairy Cattle. Animal Production Science, 52, 115-120.

Boichard D., Chung H., Dassonneville R., David X., Eggen A., Fritz S., Gietzen K.J., Hayes B.J., Lawley C.T., Sonstegard T.S., Van Tassell C.P., Vanraden P.M., Viaud K., Wiggans G.R. 2012. Design of a Bovine Low-Density SNP Array Optimized for Imputation. PLoS ONE, 7: e34130.

Capitan A., Bonnet A., Pinton A., Marquant-Le Guienne B., Le Bourhis D., Grohs C., Bouet S., Clement L., Salas-Cortes L., Venot E., Chaffaux S., Weiss B., Delpeuch A., Noe G., Rossignol M.N., Barbey S., Dozias D., Cobo E., Barasc H., Auguste A., Pannetier M., Deloche M.C., Lhuilier E., Bouchez O., Esquerre D., Salin G., Klopp C., Donnadieu C., Chantry-Darmon C., Hayes H., Gallard Y, Ponsart C., Boichard D., Pailhoux E. 2012. A 3.7 Mb deletion encompassing ZEB2 causes a novel Polled and Multisystemic Syndrome in the progeny of a somatic mosaic bull. Plos One, 7: e49084.

Dassonneville R., Baur A., Fritz S., Boichard D., Ducrocq V. 2012. Inclusion of cows records in genomic evaluations and its impact on bias due to preferential treatment. Genet. Sel. Evol., 44:40.

Dassonneville R., Fritz S., Ducrocq V., Boichard D. 2012. Imputation performances of three low density marker panels in beef and dairy cattle. Journal of Dairy Science, 95: 4136–4140.

Dayo G.K., Gautier M., Berthier D., Poivey J.P., Sidibe I., Bengaly Z., Eggen A., Boichard D., Thevenon S. 2012. Association studies in QTL regions linked to bovine trypanotolerance in a West African Crossbred Population. Animal Genetics, 43, 123-132.

Hou Y., Bickhart D.M., Hvinden M.L., Li C., Song J., Boichard D., Fritz S., Eggen A., Denise S.,  Wiggans G.R., Sonstegard T.S., Van Tassell C.P., Liu G.E. 2012. Fine mapping of copy number variations on two cattle genome assemblies using high density SNP array. BMC Genomics, 13, 376.

Ytournel F., Teyssedre S., Roldan D., Erbe M., Simianer H., Boichard D., Gilbert H., Druet T., Legarra A. 2012. LDSO: A program to simulate pedigrees and molecular information under various evolutionary forces. Journal of Animal Breeding and Genetics, 5, 417-421.

Croiseau P., Legarra A., Guillaume F., Fritz S., Baur A., Boichard D., Ducrocq V. 2011. Fine tuning genomic evaluations in dairy cattle through SNP pre-selection with the Elastic-Net algorithm. Genetics Research, 93, 409-417.

Guillaume F., Boichard D., Ducrocq V., Fritz S. 2011. Utilisation de la sélection génomique chez les bovins laitiers. INRA Prod. Anim., 24,363-368.

Barbat A., Le Mezec P., Ducrocq V., Mattalia S., Fritz S., Boichard D., Ponsart C., Humblot P. 2010. Female Fertility in French Dairy Breeds: Current Situation and Strategies for Improvement. Journal of Reproduction and Development, 56, S15-S21.

Bidanel J.P., Boichard D., Chevalet C. 2008. De la génétique à la génomique. INRA Productions Animales, 21, 15-32.

Druet T., Fritz S., Boussaha M., Ben Jemaa S., Derbala D., Zele D., Lechner D., Charon C., Boichard D., Gut I.G., Eggen A., Gautier M. 2008. Fine-mapping of QTLs affecting female fertility in dairy cattle on BTA03 using a dense SNP map. Genetics, 178, 2227-2235.

Guillaume F., Fritz S., Boichard D., Druet T. 2008. Estimation by simulation of the efficiency of the French marker-Assisted selection program in dairy cattle. Genetics Selection Evolution, 40, 91-102.

Gautier M, Fritz S., Capitan A., Eggen A., Boichard D., Druet T. 2007. Characterization of the K232A and VNTR polymorphisms in the DGAT1 gene in French dairy cattle. J. Dairy Sci, 90: 2980-2988.

Gautier M., Faraut T., Moazami-Goudarzi K., Navratil V., Foglio M., Grohs C., Boland A., Garnier J.G., Boichard D., Lathrop G.M., Gut I.G., Eggen A. 2007. Genetic and haplotypic structure in 14 European and African cattle breeds. Genetics, 177, 1059-1070.

Druet T., Fritz S., Boichard D., Colleau J.J. 2006. Estimation of genetic parameters for quantitative trait loci for dairy traits in the French Holstein population. Journal of Dairy Science, 89, 4070-4076.

Barnouin J., Chassagne M., Bazin S., Boichard D., 2004. Management and hygiene practices form questionnaire surveys in herds with very low somatic cell score through the ‘Objective Zero Mastitis’ national programme in France J Dairy Sci, 87:3989-3999.

Bennewitz J, Reinsch N., Guiard V., Fritz S., Thomsen H., Looft C., Kühn C., Schwerin M., Weimann C., Erhardt G., Reinhardt F., Reents R., Boichard D., Kalm E. 2004. Multiple Quantitative Trait Loci Mapping With Cofactors and Application of Alternative Variants of the False Discovery Rate in an Enlarged Granddaughter Design. Genetics 168: 1019–1027.

Schibler L., Roig A., Mahe M.F., Save J.C., Gautier M., Taourit S., Boichard D., Eggen A., Cribiu E.P.. 2004. A first generation bovine BAC-based physical map. Genet. Sel. Evol. 36, 105-122.

Boichard D., Grohs C., Bourgeois F., Cerqueira F., Faugeras R., Neau A., Rupp R., Amigues Y., Boscher M.Y., Leveziel H., 2003. Detection of genes influencing economic traits in three French dairy cattle breeds. Genet. Sel. Evol. 35, 77-101.

Druet T., Jaffrezic F., Boichard D., Ducrocq V., 2003. Estimation of genetic parameters for first parity lactation curves of French Holstein cows. J. Dairy Sci., 86: 2480 - 2490.

Rupp R., Boichard D., 2003. Genetics of resistance to mastitis in dairy cattle. Vet. Res., 34, 671-688.