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Virologie et Immunologie Moléculaires

Unité de Virologie et Immunologie Moléculaires

Publications

2017

Biacchesi S, Mérour E, Chevret D, Lamoureux A, Bernard J, Brémont M. NV Proteins of Fish Novirhabdovirus Recruit Cellular PPM1Bb Protein Phosphatase and Antagonize RIG-I-Mediated IFN Induction. Sci Rep.

2016

Rouxel RN, Mérour E, Biacchesi S, Brémont M. Complete Protection against Influenza Virus H1N1 Strain A/PR/8/34 Challenge in Mice Immunized with Non-Adjuvanted Novirhabdovirus Vaccines.PLoS One.

Rouxel RN, Tafalla C, Mérour E, Leal E, Biacchesi S, Brémont M. Attenuated Infectious Hematopoietic Necrosis Virus with Rearranged Gene Order as Potential Vaccine.J Virol.

Rouxel RN, Mérour E, Biacchesi S, Brémont M. Efficient Co-Replication of Defective Novirhabdovirus.Viruses.

Mérour E, Lamoureux A, Biacchesi S, Brémont M. Fine mapping of a salmonid E2 alphavirus neutralizing epitope. J Gen Virol.

Biacchesi S, Jouvion G, Mérour E, Boukadiri A, Desdouits M, Ozden S, Huerre M, Ceccaldi PE, Brémont M. Rainbow trout (Oncorhynchus mykiss) muscle satellite cells are targets of salmonid alphavirus infection. Vet Res.

2015

Souto S, Mérour E, Biacchesi S, Brémont M, Olveira JG, Bandin I. In vitro and in vivo characterization of molecular determinants of virulence in reassortant betanodavirus. J Gen Virol.

2014

Biacchesi S, Brémont M. Vaccination against Viral Hemorrhagic Septicemia and Infectious Hematopoietic Necrosis. In: Fish Vaccination. Edited by Gudding R, Lillehaug A, Evensen Ø. Chichester, UK: John Wiley & Sons, Ltd: 289–302.

Mérour E, Brémont M. Vaccination against Diseases Caused by Salmonid alphavirus. In: Fish Vaccination. Edited by Gudding R, Lillehaug A, Evensen Ø. Chichester, UK: John Wiley & Sons, Ltd: 334–340.

Vourc'h G, Halos L, Desvars A, Boué F, Pascal M, Lecollinet S, Zientara S, Duval T, Nzonza A, Brémont M. Chikungunya antibodies detected in non-human primates and rats in three Indian Ocean islands after the 2006 ChikV outbreak.Vet Res.

Nzonza A, Lecollinet S, Chat S, Lowenski S, Mérour E, Biacchesi S, Brémont M. A Recombinant Novirhabdovirus Presenting at the Surface the E Glycoprotein from West Nile Virus (WNV) Is Immunogenic and Provides Partial Protection against Lethal WNV Challenge in BALB/c Mice.PLoS One.

Einer-Jensen K, Harmache A, Biacchesi S, Brémont M, Stegmann A, Lorenzen N. High virulence differences among phylogenetically distinct isolates of the fish rhabdovirus viral hemorrhagic septicaemia virus are not explained by variability of the surface glycoprotein G or the non-virion protein Nv.J Gen Virol.

2013

Langevin C, Van Der Aa LM, Houel A, Torhy C, Briolat V, Lunazzi A, Harmache A, Brémont M, Levraud JP, Boudinot P. Zebrafish ISG15 exerts a strong antiviral activity against RNA and DNA viruses and regulates the interferon response.J Virol.

Verrier ER, Ehanno A, Biacchesi S, Le Guillou S, Dechamp N, Boudinot P, Brémont M, Quillet E. Lack of correlation between the resistances to two rhabdovirus infections in rainbow trout.Fish Shellfish Immunol.

Mérour E, Lamoureux A, Bernard J, Biacchesi S, Brémont M. A Fully Attenuated Recombinant Salmonid Alphavirus Becomes Pathogenic through a Single Amino Acid Change in the E2 Glycoprotein.J Virol.

2012

Biacchesi S, Mérour E, Lamoureux A, Bernard J, Brémont M. Both STING and MAVS Fish Orthologs Contribute to the Induction of Interferon Mediated by RIG-I.PLoS One.

2011

Choi MK, Moon CH, Ko MS, Lee UH, Cho WJ, Cha SJ, Do JW, Heo GJ, Jeong SG, Hahm YS, Harmache A., Brémont M., Kurath G, Park JW. A Nuclear Localization of the Infectious Haematopoietic Necrosis Virus NV Protein Is Necessary for Optimal Viral Growth.PLoS One.

Ludwig M, Palha N, Torhy C, Briolat V, Colucci-Guyon E, Brémont M, Herbomel P, Boudinot P, Levraud JP. Whole-Body Analysis of a Viral Infection: Vascular Endothelium is a Primary Target of Infectious Hematopoietic Necrosis Virus in Zebrafish Larvae.PLoS Pathog.

Biacchesi S.The reverse genetics applied to fish RNA viruses.Vet Res.

Park JW, Moon CH, Harmache A, Wargo AR, Purcell MK, Brémont M, Kurath G. Restricted growth of U-type infectious haematopoietic necrosis virus (IHNV) in rainbow trout cells may be linked to casein kinase II activity.J Fish Dis.

Romero A, Dios S, Brémont M, Figueras A, Novoa B. Interaction of the attenuated recombinant rIHNV-Gvhsv GFP virus with macrophages from rainbow trout (Oncorhynchus mykiss).Vet Immunol Immunopathol.

Mérour E, Le Berre M, Lamoureux A, Bernard J, Brémont M, Biacchesi S. Completion of the full-length genome sequence of the infectious salmon anaemia virus (ISAV), an aquatic orthomyxovirus-like, and characterization of monoclonal antibodies.J Gen Virol.

2010

Biacchesi S, Lamoureux A, Mérour E, Bernard J, Brémont M.Limited interference at the early stage of the infection between two recombinant Novirhabdovirus: the Viral Hemorrhagic Septicemia Virus (VHSV) and the Infectious Hematopoietic Necrosis Virus (IHNV). J Virol.

Winton J, Batts W, De Kinkelin P, LeBerre M, Brémont M, Fijan N. Current lineages of the epithelioma papulosum cyprini (EPC) cell line are contaminated with fathead minnow, Pimephales promelas, cells. J Fish Dis.

Jancovich JK, Brémont M, Touchman JW, Jacobs BL. Evidence for multiple recent host species shifts among the Ranaviruses (family Iridoviridae). J Virol.

2009

Minet C, Yami M, Egzabhier B, Gil P, Tangy F, Brémont M, Libeau G, Diallo A, Albina E. Sequence analysis of the large (L) polymerase gene and trailer of the peste des petits ruminants virus vaccine strain Nigeria 75/1: Expression and use of the L protein in reverse genetics. Virus Res.

Biacchesi S, LeBerre M, Lamoureux A, Louise Y, Lauret E, Boudinot P, Brémont M. MAVS Plays a Major Role in Induction of the Fish Innate Immune Response against RNA and DNA Viruses. J Virol.

Costes B, Raj VS, Michel B, Fournier G, Thirion M, Gillet L, Mast J, Lieffrig F, Brémont M, Vanderplasschen A. The major portal of entry of koi herpesvirus in Cyprinus carpio is the skin. J Virol.

Chérif N, Thiéry R, Castric J, Biacchesi S, Brémont M, Thabti F, Limem L, Hammami S. Viral encephalopathy and retinopathy of Dicentrarchus labrax and Sparus aurata farmed in Tunisia. Vet Res Commun.

2008

Bertagnoli S, Pignolet B, Biacchesi S, Eloit M, Klonjkowski B, Richardson J, Brémont M.Les vecteurs viraux : outils modernes de vaccination. INRA Prod Anim 21.

Romero A, Figueras A, Thoulouze MI, Brémont M, Novoa B. Recombinant infectious hematopoietic necrosis viruses induce protection for rainbow trout Oncorhynchus mykiss. Dis Aquat Organ.

2007

Quentel C, Brémont M, Pouliquen H. La vaccination chez les poissons d’élevage. INRA Prod Anim 20.

Biacchesi S, LeBerre M, Le Guillou S, Benmansour A, Brémont M, Quillet E, Boudinot P. Fish genotype significantly influences susceptibility of juvenile rainbow trout, Oncorhynchus mykiss (Walbaum), to waterborne infection with infectious salmon anaemia virus. J Fish Dis.

2006

Moriette C, LeBerre M, Lamoureux A, Lai TL, Brémont M. Recovery of a recombinant salmonid alphavirus fully attenuated and protective in rainbow trout. J Virol.

Harmache A, LeBerre M, Droineau S, Giovannini M, Brémont M.Bioluminescence imaging on live infected salmonids reveals that the fin bases are the major portal of entry for Novirhabdovirus. J Virol.

2005

Romero A, Figueras A, Tafalla C, Thoulouze MI, Brémont M, Novoa B. Histological, serological and virulence studies on rainbow trout experimentally infected with recombinant infectious hematopoietic necrosis viruses. Dis Aquat Organ.

Moriette C, LeBerre M, Kerbart Boscher S, Castric J, Brémont M. Characterization and mapping of monoclonal antibodies against the Sleeping disease virus, an aquatic alphavirus. J Gen Virol.

Brémont M. Reverse Genetics on Fish Rhabdoviruses: Tools to Study the Pathogenesis of Fish Rhabdoviruses. Curr Top Microbiol Immunol.

Moriette C, LeBerre M, Kerbart Boscher S, Castric J, Brémont M. Characterization and mapping of monoclonal antibodies against the Sleeping disease virus, an aquatic alphavirus. J Gen Virol.

2004

Boudinot P, Bernard D, Boubekeur S, Thoulouze MI, Brémont M, Benmansour A. The glycoprotein of a fish rhabdovirus profiles the virus-specific T-cell repertoire in rainbow trout. J Gen Virol.

Thoulouze MI, Bouguyon E, Carpentier C, Brémont M. Essential role of the NV protein of Novirhabdovirus for pathogenicity in rainbow trout. J Virol.

2002

Weston J, Villoing S, Brémont M, Castric J, Pfeffer M, Jewhurst V, McLoughlin M, Rodseth O, Christie KE, Koumans J, Todd D. Comparison of two aquatic alphaviruses, salmon pancreas disease virus and sleeping disease virus, by using genome sequence analysis, monoclonal reactivity, and cross-infection. J Virol.

Biacchesi S, Béarzotti M, Bouguyon E, Brémont M.Heterologous exchanges of the glycoprotein and the matrix protein in a Novirhabdovirus. J Virol.

2001

Essbauer S, Brémont M, Ahne W. Comparison of the eIF-2alpha homologous proteins of seven ranaviruses (Iridoviridae). Virus Genes.

2000

Biacchesi S, Thoulouze MI, Béarzotti M, Yu YX, Brémont M. Recovery of NV knockout infectious hematopoietic necrosis virus expressing foreign genes. J Virol.

Biacchesi S, Yu YX, Béarzotti M, Tafalla C, Fernandez-Alonso M, Brémont M. Rescue of synthetic salmonid rhabdovirus minigenomes. J Gen Virol.

Villoing S, Béarzotti M, Chilmonczyk S, Castric J, Brémont M. Rainbow trout sleeping disease virus is an atypical alphavirus. J Virol.

Villoing S, Castric J, Jeffroy J, Le Ven A, Thiéry R, Brémont M. An RT-PCR-based method for the diagnosis of the sleeping disease virus in experimentally and naturally infected salmonids. Dis Aquat Organ.

1999

Béarzotti M, Delmas B, Lamoureux A, Loustau AM, Chilmonczyk S, Brémont M. Fish rhabdovirus cell entry is mediated by fibronectin. J Virol.

Yu YX, Béarzotti M, Vende P, Ahne W, Brémont M. Partial mapping and sequencing of a fish iridovirus genome reveals genes homologous to the frog virus 3 p31, p40 and human eIF2alpha. Virus Res.

1998

Ahne W, Béarzotti M., Brémont M, Essbauer S. Comparison of European systemic piscine and amphibian iridoviruses with epizootic haematopoietic necrosis virus and frog virus 3. Zentralbl Veterinarmed.

Said T, Bruley H, Lamoureux A, Brémont M. An RNA-binding domain in the viral haemorrhagic septicaemia virus nucleoprotein. J Gen Virol.

1996

Saulnier D, Brémont M, De Kinkelin P. Cloning, sequencing and expression of a cDNA encoding an antigen from the Myxosporean parasite causing the proliferative kidney disease of salmonid fish. Mol Biochem Parasit.

1995

Béarzotti M, Lamoureux A, Chilmonczyk S, Brémont M. Identification of a cellular receptor for fish rhabdoviruses. Vet Res.

Bernard J, Brémont M. Molecular biology of fish viruses: a review. Vet Res.

Said T, Bruley H, Lamoureux A, Brémont M. Delineation of an RNA-binding region in the viral hemorrhagic septicemia virus nucleoprotein. Vet Res.

Vautherot D, Lamoureux A, Chilmonczyk S, Brémont M. Expression of viral hemorrhagic septicemia virus structural proteins in the baculovirus expression system, Vet Res.

1992

Bernard J, Bremont M, Winton J. Nucleocapsid gene sequence of a North American isolate of viral haemorrhagic septicaemia virus, a fish rhabdovirus. J Gen Virol.