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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal AgroParisTech Université Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

A comprehensive and structured research facility to meet the challenges of integrative biology

BIGE combines integrative biology, genomic and genetic analyses to improve horse breed selection for the different equine sports and to improve the diagnostic of equine genetic diseases. Musculo-skeletal development, maintenance and pathologies are studied by including all “OMIC” approaches in order to determine the molecular mechanism underlying these phenotypes, to identify putative biomarkers and to propose genotyping methods.

Our main mission is through genetic approaches, to contribute to the sustainability of bovine production in its economic, social and environmental dimensions. Our activities are based on a strong synergy between genomic selection and analysis of genetic variability. These two key topics take full advantage of new genotyping and high-throughput sequencing techniques and bioinformatics.

GenAqua’s overall project aims at producing the knowledge necessary to implement efficient genetic management and selective breeding of fish (mostly for aquaculture, but also for stocking). Rainbow trout, sea bass and brown trout are the main target species. The project includes the development of genomic resources, analysis of the genetic architecture of important traits and development of efficient breeding schemes that are adapted both to the biological specificities of fish and the French socio-economical context.

The specific nature of our research is that it concerns mammary gland development and lactation functions in animals, our aim objective is to improve milk quality and production in dairy ruminants.

The team Genetics, Immunity and Health groups together INRA and CEA scientists with the aim to combine research on immunogenetics and response to diseases on model and livestock species:

  1. genetics and immunology of tumour development and regression in the pig MeLiM model of the human cutaneous melanoma,
  2. genetic architecture of immunity traits and response to infectious diseases (pig and chicken),
  3. comparative biology of the Major Histocompatibility Complex (MHC) region (pig, chicken, rabbit).

The LGS team is positioned within the GABI unit as the component that brings together genomics and biology of lactation and is centred on "Genome and Milk Quality", but it is also the foundation on which relies an open core facility (ICE Iso Cell Express) that provides integrated technological solutions for micro-genomics. Major themes of LGS concern the genome and the consequences of its variability on milk composition, in connection with udder health, the development of the intestine in the young and the consumer’s health.

The MoDiT team, created beginning of 2014, analyzes the biological function of genes acting on tissue development and/or differentiation or genes found to be associated with early developmental abnormalities that could affect the nervous system. These genetic diseases include ataxias and axonopathies, identified through our involvement in ONAB (National Observatory of Bovine Anomalies). All these genes have largely unknown function and are expressed in various tissues, if not ubiquitously. Our studies are based on the production of mouse transgenic models.

The team gathers the expertise and the equipments of the facilities supported by GABI which are open to external users:  the @BRIDGe facility (animal Biological Resources for Integrated and Digital Genomics), the histology facility, and the Transmission Electron Microscopy service of the MIMA2 multi-centric facility.

The team is structured around three axes: (i) Population genetics and genetic resources, (ii) Biostatistics and (iii) Animal experimentation in experimental lines (poultry, quail). By nature, with four AgroParisTech staff within the team, an important part of its activity is dedicated to education and training.