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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal AgroParisTech Université Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

Animal Models for the Differentiation of Tissues (MoDiT)

Team leader: Jean-Luc Vilotte (jean-luc.vilotte@jouy.inra.fr)

Team

  • Maud Bertaud,
  • Johan Castille,
  • Edmond Cribiu,
  • Amandine Duchesne,
  •  Sandrine Floriot,
  • Pascal Laurent,
  • Samira Makhzami,
  • Katayoun Moazami-Goudarzi,
  • Bruno Passet,
  • Jean-Luc Vilotte,
  • Marthe Vilotte.

Team's field of research

ModiT(4)

The MoDiT team, created beginning of 2014, analyzes the biological function of genes acting on tissue development and/or differentiation or genes found to be associated with early developmental abnormalities that could affect the nervous system. These genetic diseases include ataxias and axonopathies, identified through our involvement in ONAB (National Observatory of Bovine Anomalies).

All these genes have largely unknown function and are expressed in various tissues, if not ubiquitously. Our studies are based on the production of mouse transgenic models.

Research themes

These projects use transgenic models and involve the entire MoDiT team. The mentioned names are those of the "corresponding" scientists.

- Analysis of the biological role of the prion proteins, link with multiple developmental abnormalities.Bruno Passet, Katayoun Moazami-Goudarzi.

- Analysis of CEP250 function, link with the SHGC pathology.Sandrine Floriot, Edmond Cribiu.

- Analysis of SLC25a46 function, link with distal and peripheral axonopathy.Amandine Duchesne.

- Search for and analysis of the locus responsible of progressive ataxia in the Charolais breed. Sandrine Floriot, Amandine Duchesne.

Collaborations and Partnerships

Placental developmental abnormalities: role of Stox1.Daniel Vaiman (INSERM, U1016)

Doridot L., Passet B, Rigourd V, Méhats C, Barbaux S, Mondon F, Vilotte M, Castille J, Breuiller-Fouche M, Jacques S, Daniel N, Le Provost F, Bauchet AL, Hertig A, Buffat C, Simeoni U, Germain G, Vilotte JL, Vaiman D Mice overexpressing STOX1 are preeclamptic. Hypertension 2013, 61, 662-668.

PrP Proteins, stem cells and pathologies.Sophie Mouillet-Richard (INSERM, UMRS-747), Vincent Béringue et Sophie Halliez (INRA, UMR1157).

Béringue V, Herzog L, Jaumain E, Reine F, Sibille P, Le Dur A, Vilotte JL, Laude H. Facilitated cross-species transmission of prions in extraneural tissue. Science. 2012 335:472-5.

Major loci involved in gonadic differentiation.Eric Pailhoux (INRA, UMR1198)

Boulanger L, Kocer A, Daniel N, Pannetier M, Chesné P, Heyman Y, Renault L, Mandon-Pépin B, Chavatte-Palmer P, Vignon X, Vilotte JL, Cotinot C, Renard JP, Pailhoux E. (2008) Attempt to Rescue Sex-Reversal by Transgenic Expression of the PISRT1 Gene in XX PIS Goats. Sex Dev. 2008;2(3):142-151.

Major loci involved in muscular development.Véronique Blanquet (INRA, UMR1061). 

Monestier O, Brun C, Heu K, Passet B, Malhouroux M, Magnol L, Vilotte JL, Blanquet V. Ubiquitous Gasp1 overexpression in mice leads mainly to a hypermuscular phenotype. BMC Genomics. 2012, 13(1):541.

Experimental facilities

- Infectiologie Expérimentale Rongeurs et Poissons-Jouy-en-Josas

Major publications 

Chadi S, Young R, Le Guillou S, Tilly G, Bitton F, Martin-Magniette ML, Soubigou-Taconnat L, Balzergue S, Vilotte M, Peyre C, Passet B, Béringue V, Renou JP, Le Provost F, Laude H, Vilotte JL. Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse. BMC Genomics. 2010 Jul 22;11:448.

Khalifé M, Young R,  Passet B, Halliez S, Vilotte M,  Jaffrezic F, Marthey S, Béringue V, Vaiman D,  Le Provost F, Laude H, Vilotte JL, Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis. Plos One 2011; 6(8):e23253.

Passet B, Young R,  Makhzami S, Vilotte M, Jaffrezic F, Halliez S, Bouet S, Marthey S,  Khalifé M, Kanellopoulos-Langevin C, Béringue V, Le Provost F, Laude H, Vilotte JL Prion protein and Shadoo are involved in overlapping embryonic pathways and trophoblastic development. Plos One 2012, 7(7):e41959.

Passet B, Halliez S, Béringue V, Laude H, Vilotte JL. The prion protein family: Looking outside the central nervous system. Prion. 2013 7: 127-130.