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Dernière mise à jour : Mai 2018

Menu Logo Principal AgroParisTech Université Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

PSGen: Populations, Statistics and Genome

The "Populations, Statistics and Genome" or PSGen team addresses issues related to genetic diversity of animal populations, statistical analysis of genetic variability and the consequences on the outcome of certain biological functions of gene structure and expression variation.

The members of the PSGen team have very diversified and complementary expertise in the three fields of study and part of the members are very active in teaching.

► Fine analysis of functional variation

This theme is based on animal experimentation. It is mainly orientated towards poultry (chickens and quail) for which original populations are available: selected lines and "resource" herds. Our studies are aimed at analyzing precisely genes with visible effects, such as coloration genes. The overall approach ranges from exploring phenotypic variation to identifying causal mutations and, when possible, to concluding on the evolutionary history of species. In fact, in-depth investigations are carried out extending to the analysis of gene expression, of functions associated with animal adaptation or health, including thermotolerance, immunity and robustness, for example.

Methodology

By its nature, our research leads to generic studies. The main objective is to provide methodological innovations in statistical genetics and population genetics with various applications. Within the field of statistical genetics, special emphasis is placed on the Bayesian approach of the mixed model and one group of studies is focused on analytical methods for transcriptomics and gene network data. Theoretical developments concern the genetics of chromosomal segments to model the bases of the selection response. In population genetics, our studies aim at analysing the linkage disequilibrium of genes and at identifying selection signatures during the history of populations.

Genetic resource engineering

This field is developed on a wide variety of farming species and when possible in their wild location. We work with organizations in charge of population management and can offer help from diagnostics to recommendations. Studies on the inventory and characterization of local farming populations are performed in the southern countries. We analyze the polymorphisms and genetic structure of populations in a wide variety of situations by combining genealogical and molecular information. We also analyze the impact of selection on the genetic variability of populations along with the efficacy of conservation measures, in situ or in cryobanks. Finally, studies are perfomed on the conditions and consequences of the valorization of local breeds.

 Teaching

Our teaching activities are mainly part of the missions of the professors of the AgroParisTech (Paris Institute of Technology for Life, Food and Environmental Sciences), who in the GABI laboratory all work in the PSGen team. Amongst these missions are the following:

  • general teaching and specialized training in Animal Productions of AgroParisTech engineering students,
  • specialized training in Animal Genetics, within the framework of the EM-ABG European Master program,
  • follow-up tutoring of doctoral students and teaching doctoral courses,
  • continued education (CSAGAD Advanced Course on Genetic Improvement of Domestic Animals) and
  • on-line training within the framework of the Ge-Net network; other programs (ENSAI, National School for Statistics and Information Analysis) or dissemination and popularization activities (AppliBugs, Monolix) concern more specifically statistical genetics.