Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free: https://www.ghostery.com/fr/products/

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site: http://www.youronlinechoices.com/fr/controler-ses-cookies/, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Realytics
Google Analytics
Spoteffects
Optimizely

Targeted advertising cookies

DoubleClick
Mediarithmics

The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at cil-dpo@inra.fr or by post at:

INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal AgroParisTech Université Paris-Saclay

INRA GABI Unit

GABI : Génétique Animale et Biologie IntégrativeUnité Mixte de Recherche INRA - AgroParisTech

Eric Barrey, Senior Research Scientist

BARREY Eric
Topics: Equine Genomics, muscular and mitochondrial functional genomics, miRNA and mitochondria crosstalk with the nuclear genome

INRA, UMR 1313 Génétique Animale et Biologie Intégrative
Domaine de Vilvert, Bat 211, 78352 Jouy en Josas
Tel : +33 (0) 1 34 65 29 53   Fax  : +33 (0) 1 34 65 22 10

Email :eric.barrey@jouy.inra.fr

Research unit: Animal Genetics and Integrative Biology (GABI)

Research Team: Integrative Biology and Equine Genetics (BIGE)

Track record

My clinician background is strengthened with knowledge on integrative of biology in exercise physiology, quantitative genetics and genomics. My scientific career has taken atypical paths allowing an integrative biology approach of functional genomics in muscular exercise in order to progress in animal and human health.

• Outstanding Position (2013): Research Director, Team leader of Integrative Biology and Equine Genetics (BIGE), INRA, Jouy-en-Josas, France.

• 2004-2013: Team leader of functional genomics in muscular exercise, Laboratory of Integrative Biology of Exercise Adaptations (UBIAE), Inserm U902, Genopole, Université d'Evry Val d’Essone, 91025 Evry, France.

• 1990-2004: Research Associate at the Animal Genetics Department (Station de Génétique Quantitative et Appliquée,  Team of Equine genetics), INRA, Jouy-en-Josas, France.

• 1987-90: PhD and Assistant in the Nutrition and Exercise Laboratory of the Veterinary School of Alfort (ENVA), France.

• 1987-90: PhD Thesis, ENSAM, Paris. 1st Price of the French Biomechanics Society.

• 1987: Doctor in Veterinary Medicine (DVM), Alfort Veterinary School (DVM)

Fields of Research

Since 2004 my main research objective was to study muscular functional genomics in normal, pathological or treated muscle. Genomic functional disorders in two equine myopathies PSSM and RER were explored using expression microarrays and data mining methods.

In 2011, a scientific breakthrough in mitochondrial crosstalk was the discovery of pre-microRNAs and mature miRNAs encoded by the nuclear genome localized in mitochondria of human myocytes and the in silico prediction of putative miRNA sequences and targets on mtDNA. The paper has been published in PlosOne 2011:

Barrey E, Saint-Auret G, Bonnamy B, Damas D, Boyer O, Gidrol X. (2011) Pre-microRNA and mature microRNA in human mitochondria.PLoS One. 2011;6(5):e20220.

The metrics today indicated more than 15000 views, 42 citations. The results of this paper were confirmed by several other papers and new regulation functions of several miRNA localized to mitochondrial has been discovered. Recently, two miRNAs encoded  by the mitochondrial genome and derived from the 16S transcript were identified.  Other putative miRNAs derived from mtDNA transcription are studied in our team.   

Other Activites

Chaiman of international  conferences:

• 2002-2006: Chairman of the 7th International conference on equine exercise physiology, ICEEP 7, Fontainebleau, France, 26-31 August 2006. Peer reviewed proceedings published in Equine Vet. Journal.

• 1996: Chairman of the 3rd International Workshop on Animal Locomotion (IWAL 3) and editor of the peer reviewed proceedings published in Equine Vet. Journal.

• 1998-2010: Member of the international scientific committee of the 5th, 6th, 7th, 8th International conference on equine exercise physiology in Japan, Kentucky (USA) and South Africa, respectively.

Innovation, transfer and consulting:

An original gait analysis systems based on body 3-dimensional acceleration measurements and softwares for automatic  gait analysis has been developped at INRA in the 90's for phenotyping horses exercise ability (Equimetrix®). A technological transfer has been performed for human medical and sports applications (Locometrix®). Medical applications in neurology, rehabilitation, geriatrics, rheumatology, physiotherapy and sport medicine are used in hospitals, rehabilitation centres in Europe. Locometrix® is used in ongoing clinical trials in myology. Co-founder and scientific consultant of Centaure Metrix, a start-up company lauched in 2001.

Publications

Patents:

• 2001: Procédé d’analyse d’irrégularité de locomotion humaine: French Patent N°FR 2804596; European Patent N°EP 1261279B1; Canada N° 2,399,182; Method for analyzing irregularities in human locomotion: USA Patent N° P 680 079 US0; Centaure Metrix SAS have the exclusive license of the patents since 2001. More than 140 units were sold in Europe.

• 1989: Plaque orthopédique de maréchalerie pour sabot de cheval . French Patent N°89 01233. Damping pads to reduce the high frequency shocks that distroy articular cartilages in equine athletes. 1st Price Biochance from Lille district. Exclusive license of the patent was used during 20 years by a French chemical company Saint Gobain SA. About one million damping pads were sold to prevent digital arthrosis in sport horses.

Book chapters:

Barrey E (2012). Chapter 21: Genetics and genomics of equine athletes, In Hinchcliff, Kaneps & Geor (Eds). Equine Sports and Surgery, Elsevier, Oxford (2nd edition).

Barrey E (2012). Chapter 12: Biomechanics of locomotion in athletic horse, In Hinchcliff, Kaneps & Geor (Eds). Equine Sports and Surgery, Elsevier, Oxford (2nd edition).

BARREY E., (2001). Inter-limb coordination. In BACK W., CLAYTON H. (Eds.), "Equine locomotion", 77-94, W.B. Saunders.

BARREY E., (2000). Métodos de analisis de la locomocion equina: uso de acelerometros. In RIVERO J.L.L., "Locomocion del caballo. Métodos de analisis. Evaluacion funcional. Diagnostico de cojeras", 15-80, Universidad de Cordoba, Servicio de Reprografia, Cordoba, Spain.

SAASTAMOINEN M.T., BARREY E. (2000). Genetics of conformation, locomotion and physiological traits. In BOWLING A.T., RUVINSKY A. (Eds.), "The genetics of the horse", 439-472, CAB International, Oxon, UK.

Omics and muscular exercise

Le Moyec L, Robert C, Triba MN, Billat VL, Mata X, Schibler L, Barrey E. Protein catabolism and high lipid metabolism associated with long-distance exercise are revealed by plasma NMR metabolomics in endurance horses. PLoS One. 2014 Mar 21;9(3):e90730. doi: 10.1371/journal.pone.0090730.eCollection 2014.

Desjardin C, Vaiman A, Mata X, Legendre R, Laubier J, Kennedy SP, Laloe D, Barrey E, Jacques C, Cribiu EP, Schibler L. Next-generation sequencing identifies equine cartilage and subchondral bone miRNAs and suggests their involvement in osteochondrosis physiopathology. BMC Genomics. 2014 Sep 17;15:798. doi: 10.1186/1471-2164-15-798.

Mille-Hamard L, Billat VL, Henry E, Bonnamy B, Joly F, Benech P, Barrey E. Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative study. BMC Med Genomics. 2012 Jun 29;5:29. doi: 10.1186/1755-8794-5-29.

Barrey E, Saint-Auret G, Bonnamy B, Damas D, Boyer O, Gidrol X. (2011) Pre-microRNA and mature microRNA in human mitochondria. PLoS One. 2011;6(5):e20220.

Bandiera S, Barrey E, Ernoult-Lange M, Gidrol X, Henrion-Caude A, Huang L, Saint-Auret G, Weil D (all authors had the same contribution to this review) (2012). News - La mitochondrie : un nouvel acteur de la régulation par ARN interférence. Medecine/Sciences  28, 15-17. IF 0.64.

Barrey E, Jayr L, Mucher E, Gospodnetic S, Joly F, Benech P, Alibert O, Gidrol X, Mata X, Vaiman A, Guérin G (2011) Muscular transcriptomic analysis in horses suffering from recurrent exertional rhabdomyolysis revealed energetic pathway alterations and disruption in the cytoplasmic calcium regulation. Animal Genetics (online: 27 SEP 2011 | DOI: 10.1111/j.1365-2052.2011.02246.x) IF 2.203.

Barrey E, Bonnamy B, Barrey EJ, Mata X, Chaffaux S and Guerin G (2010) Muscular microRNA expressions in healthy and myopathic horses suffering from polysaccharide storage myopathy or recurrent exertional rhabdomyolysis. Equine Vet. J. (2010) 42 (Suppl. 38) 303-310. IF 1.799; cited 3.

Capomaccio S, Cappelli K, Barrey E, Felicetti M, Silvestrelli M, Verini-Supplizi A. Microarray analysis after strenuous exercise in peripheral blood mononuclear cells of endurance horses. Anim Genet. 2010 Dec;41 Suppl 2:166-75. doi: 10.1111/j.1365-2052.2010.02129.x.

Barrey E, Mucher E, Jeansoule N, Larcher T, Guigand L, Herszberg B, Chaffaux S, Guérin G, Mata X, Benech P, Canale M, Alibert O, Maltere P, Gidrol X (2009). Gene expression profiling in equine polysaccharide storage myopathy revealed inflammation, glycogenesis inhibition, hypoxia and mitochondrial dysfunctions. BMC Vet Res. Aug 7;5:29. PubMed Central PMCID:PMC2741442. IF 2.371; cited 7.

Barrey E, Mucher E, Robert C, Amiot F, Gidrol X (2006). Gene expression profiling in blood cells of endurance horses completing competition or disqualified due to metabolic disorder. Equine Vet J Suppl. 36: 43-9. IF ; IF 1.799; cited 17.

Mucher E, Jayr L, Rossignol F, Amiot F, Gidrol X, Barrey E (2006). Gene expression profiling in equine muscle tissues using mouse cDNA microarrays. Equine Vet J Suppl. 36: 359-64. IF 1.799; cited 8.

Integrative biology

López-Sanromán FJ, Holmbak-Petersen R, Santiago I, Gómez de Segura IA, Barrey E (2011). Gait analysis using 3D accelerometry in horses sedated with xylazine. Vet J  Nov 12.  IF 2.644.

Cottin F, Metayer N, Goachet Ag, Julliand V, Slawinski J, Billat V And Barrey E (2010). Oxygen consumption and gait variables of Arabian endurance horses measured during a field exercise test. Equine Vet J  42 (Suppl. 38) 1-5. IF 1.799.

Leprêtre PM, Metayer N, Giovagnoli G, Pagliei E, Barrey E (2009). Comparison of analyses of respiratory gases made with the K4b2 portable and Quark laboratory analysers in horses. Vet Rec 165(1):22-5. IF 1.482; cited 1.

Le Bris R, Billat V, Auvinet B, Chaleil D, Hamard L, Barrey E (2006). Effect of fatigue on stride pattern continuously measured by an accelerometric gait recorder in middle distance runners. J Sports Med Phys Fitness 46 (2): 227-31. IF 0.80; cited 6.

Leleu C, Bariller F, Cotrel C, Barrey E (2004). Reproducibility of a locomotor test for trotter horses. Vet J  168:160-6. IF 2.644; cited 4.

Leleu C, Gloria E, Renault G, Barrey E (2002). Analysis of trotter gait on the track by accelerometry and image analysis. Equine Vet J Suppl. 34: 344-8. IF 1.799; cited 1.

Innovation & transfer

Mignardot JB, Deschamps T, Barrey E, Auvinet B, Berrut G, Cornu C, Constans T, de Decker L. Gait disturbances as specific predictive markers of the first fall onset in elderly people: a two-year prospective observational study. Front Aging Neurosci. 2014 Feb 25;6:22. doi: 10.3389/fnagi.2014.00022. eCollection 2014.

Barthélémy I, Barrey E, Aguilar P, Uriarte A, Le Chevoir M, Thibaud JL, Voit T, Blot S, Hogrel JY. Longitudinal ambulatory measurements of gait abnormality in dystrophin-deficient dogs. BMC Musculoskelet Disord. 2011 Apr 13;12:75. doi: 10.1186/1471-2474-12-75.

Barthélémy I, Barrey E, Thibaud JL, Uriarte A, Voit T, Blot S, Hogrel JY. Gait analysis using accelerometry in dystrophin-deficient dogs. Neuromuscul Disord. 2009 Nov;19(11):788-96. doi: 10.1016/j.nmd.2009.07.014. Epub 2009 Oct 1.

López-Sanromán FJ, Holmbak-Petersen R, Santiago I, Gómez de Segura IA, Barrey E. Gait analysis using 3D accelerometry in horses sedated with xylazine. Vet J. 2012 Jul;193(1):212-6. doi: 10.1016/j.tvjl.2011.10.012. Epub 2011 Nov 13.

Auvinet B, Bileckot R, Alix AS, Chaleil D, Barrey E (2006) Gait disorders in patients with fibromyalgia. Joint Bone Spine. Oct;73(5):543-6. Epub 2006 Mar 15. IF 2.460; cited 15.

Paquet JM, Auvinet B, Chaleil D, Barrey E (2003) Analysis of gait disorders in Parkinson's disease assessed with an accelerometer. Rev Neurol (Paris). 2003 Sep;159(8-9):786-9. IF 0.61; cited 5.

Auvinet B, Berrut G, Touzard C, Moutel L, Collet N, Chaleil D, Barrey E (2002). Reference data for normal subjects obtained with an accelerometric device. Gait & Posture 16(2): 124-34. IF 2.936; cited 92.