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Virologie et Immunologie Moléculaires

Unité de Virologie et Immunologie Moléculaires

Equipe Virus Influenza



Barthelemy A, Sencio V, Soulard D, Deruyter L, Faveeuw C, Le Goffic R, Trottein F. 
Interleukin-22 Immunotherapy during Severe Influenza Enhances Lung Tissue Integrity and Reduces Secondary Bacterial Systemic Invasion.
Infect Immun. 21;86(7).

Anchim A, Raddi N, Zig L, Perrieau P, Le Goffic R, Ryffel B, Benihoud K.
Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway.
Front Immunol. 9:124.

Cagno V, Andreozzi P, D'Alicarnasso M, Jacob Silva P, Mueller M, Galloux M, Le Goffic R, Jones ST, Vallino M, Hodek J, Weber J, Sen S, Janeček ER, Bekdemir A, Sanavio B, Martinelli C, Donalisio M, Rameix Welti MA, Eleouet JF, Han Y, Kaiser L, Vukovic L, Tapparel C, Král P, Krol S, Lembo D, Stellacci F.
Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism. 
Nat Mater. 17(2):195-203.


Meyer L, Leymarie O, Chevalier C, Esnault E, Moroldo M, Da Costa B, Georgeault S, Roingeard P, Delmas B, Quere P, and Le Goffic R.
Transcriptomic profiling of a chicken lung epithelial cell line (CLEC213) reveals a mitochondrial respiratory chain activity boost during influenza virus infection.
PLoS One 12(4):e0176355.

Gaillard V, Galloux M, Garcin D, Eleouet JF, Le Goffic R, Larcher T, Rameix-Welti MA, Boukadiri A, Heritier J, Segura JM, Baechler E, Arrell M, Mottet-Osman G, and Nyanguile O.
A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading.
Antimicrob Agents Chemother 61(4).

Deloizy C, Fossum E, Barnier-Quer C, Urien C, Chrun T, Duval A, Codjovi M, Bouguyon E, Maisonnasse P, Hervé PL, Barc C, Boulesteix O, Pezant J, Chevalier C, Collin N, Dalod M, Bogen B, Bertho N, Schwartz-Cornil I.
The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin.
 Sci Rep. 9;7(1):7639.

Gaelings L, Soderholm S, Bugai A, Fu Y, Nandania J, Schepens B, Lorey MB, Tynell J, Vande Ginste L, Le Goffic R, Miller MS, Kuisma M, Marjomaki V, De Brabander J, Matikainen S, Nyman TA, Bamford DH, Saelens X, Julkunen I, Paavilainen H, Hukkanen V, Velagapudi V, and Kainov DE.
Regulation of kynurenine biosynthesis during influenza virus infection.
FEBS J 284(2):222-236.

Leymarie O, Meyer L, Herve PL, Da Costa B, Delmas B, Chevalier C, and Le Goffic R.
Host Response Comparison of H1N1- and H5N1-Infected Mice Identifies Two Potential Death Mechanisms.
Int J Mol Sci 18(8).

Leymarie O, Meyer L, Tafforeau L, Lotteau V, Da Costa B, Delmas B, Chevalier C, and Le Goffic R.
Influenza virus protein PB1-F2 interacts with CALCOCO2 (NDP52) to modulate innate immune response.
J Gen Virol 98(6):1196-1208.


Bernelin-Cottet C, Deloizy C, Stanek O, Barc C, Bouguyon E, Urien C, Boulesteix O, Pezant J, Richard CA, Moudjou M, Da Costa B, Jouneau L, Chevalier C, Leclerc C, Sebo P, Bertho N, Schwartz-Cornil I.
A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies
Front Immunol. 26;7:641.

Vidy A, Maisonnasse P, Da Costa B, Delmas B, Chevalier C, Le Goffic R.
The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition.
PLoS One. 11(10):e0165361. 

Chevalier C, Le Goffic R, Jamme F, Leymarie O, Réfrégiers M, Delmas B.
Synchrotron Infrared and Deep UV Fluorescent Microspectroscopy Study of PB1-F2 β-Aggregated Structures in Influenza A Virus-Infected Cells.
J Biol Chem. 291:9060-9072. 

Meyer L, Sausset A, Sedano L, Da Costa B, Le Goffic R, Delmas B.
Codon deletions in the influenza A virus PA gene generate temperature-sensitive viruses.
J Virol 90:3684-3693.

Ajjaji D, Richard CA, Mazerat S, Chevalier C, Vidic J.
N-terminal domain of PB1-F2 protein of influenza A virus can fold into amyloid-like oligomers and damage cholesterol and cardiolipid containing membranes.
Biochemical and biophysical research communications. 477(1):27-32.

Maisonnasse P, Bouguyon E, Piton G, Ezquerra A, Urien C, Deloizy C, Bourge M, Leplat JJ, Simon G, Chevalier C, Vincent-Naulleau S, Crisci E, Montoya M, Schwartz-Cornil I, Bertho N.
The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model.
Mucosal immunology. 9(4):835-49.

Vidic J, Richard CA, Péchoux C, Da Costa B, Bertho N, Mazerat S, Delmas B, Chevalier C.
Amyloid Assemblies of Influenza A Virus PB1-F2 Protein Damage Membrane and Induce Cytotoxicity.
The Journal of biological chemistry. 291(2):739-51.

Vidic J, Noiray M, Bagchi A, Slama-Schwok A.
Identification of a Novel Complex between the Nucleoprotein and PA(1-27) of Influenza A Virus Polymerase.
Biochemistry. 9;55(31):4259-62.


Torrent J, Vilchez-Acosta A, Munoz-Torrero D, Trovaslet M, Nachon F, Chatonnet A, Grznarova K, Acquatella-Tran Van Ba I, Le Goffic R, Herzog L, Beringue V, Rezaei H.
Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases.
Acta Neuropathol Commun 3: 18.

Da Costa B, Sausset A, Munier S, Ghounaris A, Naffakh N, Le Goffic R, Delmas B.
Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation.
J Virol 89: 6376-6390.

Mahjoub N, Dhorne-Pollet S, Fuchs W, Endale Ahanda ML, Lange E, Klupp B, Arya A, Loveland JE, Lefevre F, Mettenleiter TC, Giuffra E. 
A 2.5-kilobase deletion containing a cluster of nine microRNAs in the latency-associated-transcript locus of the pseudorabies virus affects the host response of porcine trigeminal ganglia during established latency
J Virol 89(1):428-42.

Monod A, Swale C, Tarus B, Tissot A, Delmas B, Ruigrok RW, Crépin T, Slama-Schwok A.
Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza.
Expert Opin Drug Discov. 10(4):345-71.


Gault Z, Rameix-Welti MA, Le Goffic R.
Virus influenza.
EMC Biologie médicale, Elsevier Masson.

Rameix-Welti MA, Le Goffic R, Hervé PL, Sourimant J, Riffault S, Yu Q, Galloux M, Gault E, Eléouët JF.
RSV reporter viruses for in vitro and in vivo non-invasive imaging.
Nat Commun. 3;5:5104
Commentaire de cet article sur Futura-sciences.com
Communiqué de presse sur inra.fr

Vidic J, Haque F, Guigner JM, Vidy A, Chevalier C, Stankic S.
Effects of water and cell culture media on the physicochemical properties of ZnMgO nanoparticles and their toxicity toward mammalian cells.
Langmuir. 30(38):11366-74.

Miodek A, Vidic J, Sauriat-Dorizon H, Richard CA, Le Goffic R, Korri-Youssoufi H, Chevalier C.
Electrochemical detection of the oligomerization of PB1-F2 influenza A virus protein in infected cells.
Anal Chem. 86(18):9098-105.

Leymarie O, Embury-Hyatt C, Chevalier C, Jouneau L, Moroldo M, Da Costa B, Berhane Y, Delmas B, Weingartl HM, Le Goffic R.
PB1-F2 attenuates virulence of highly pathogenic avian H5N1 influenza virus in chickens.
PLoS One. 9(6):e100679.

Miodek A, Sauriat-Dorizon H, Chevalier C, Delmas B, Vidic J, Korri-Youssoufi H.
Direct electrochemical detection of PB1-F2 protein of influenza A virus in infected cells.
Biosensors and Bioelectronics. 59C:6-13.

Pontes D, Azevedo M, Innocentin S, Blugeon S, Lefévre F, Azevedo V, Miyoshi A, Courtin P, Chapot-Chartier MP, Langella P, Chatel JM.
Immune Response Elicited by DNA Vaccination Using Lactococcus lactis Is Modified by the Production of Surface Exposed Pathogenic Protein.
PLoS One. 9(1):e84509.

Hervé PL, Raliou M, Bourdieu C, Dubuquoy C, Petit-Camurdan A, Bertho N, Eléouët JF, Chevalier C, Riffault S.
A novel subnucleocapsid nanoplatform for mucosal vaccination against influenza virus that targets the ectodomain of matrix protein 2.
J Virol. 88(1):325-38.


Chenavas S, Crépin T, Delmas B, Ruigrok RW, Slama-Schwok A.
Influenza virus nucleoprotein: structure, RNA binding, oligomerization and antiviral drug target.
Future Microbiol. 8:1537-45.

Vidic J, Le Goffic R, Miodek A, Bourdieu C, Richard CA, Moudjou M, Delmas BChevalier C.
Detection of soluble oligomers formed by PB1-F2 Influenza A virus protein in vitro.
Journal of Analytical & Bioanalytical Techniques. Volume 4 • Issue 3 • 1000169.

Vidic J, Chevalier CLe Goffic R, Miodek A, Bourdieu C, Richard CA, Moudjou M, Delmas B.
Surface Plasmon Resonance Immunosensors for Detection of PB1-F2 Influenza A Virus Protein in Infected Biological Samples.
Journal of Analytical & Bioanalytical Techniques. S7: 006.

Gibrat JF, Mariadassou M, Boudinot P, Delmas B.
Analyses of the radiation of birnaviruses from diverse host phyla and of their evolutionary affinities with other double-stranded RNA and positive strand RNA viruses using robust structure-based multiple sequence alignments and advanced phylogenetic methods.
BMC Evol Biol. 13:154.

Chenavas S, Estrozi LF, Slama-Schwok A, Delmas B, Di Primo C, Baudin F, Li X, Crépin T, Ruigrok RW. 
Monomeric nucleoprotein of influenza A virus.
PLoS Pathogens. 9(3):e1003275.

Daniel-Carlier N, Sawafta A, Passet B, Thépot D, Leroux-Coyau M, Lefèvre F, Houdebine LM, Jolivet G.
Viral infection resistance conferred on mice by siRNA transgenesis.
Transgenic Research. 22(3):489-500.

Doceul V, Lara E, Sailleau C, Belbis G, Richardson J, Bréard E, Viarouge C, Dominguez M, Hendrikx P, Calavas D, Desprat A, Languille J, Comtet L, Pourquier P, Eléouët JF, Delmas B, Marianneau P, Vitour D, Zientara S.
Epidemiology, molecular virology and diagnostics of Schmallenberg virus, an emerging orthobunyavirus in Europe.
Veterinary Research. 44(1):31.

Vidic J, Stankic S, Haque F, Ciric D, Le Goffic R, Vidy A, Jupille J, Delmas B.
Selective antibacterial effects of mixed ZnMgO nanoparticles.
J Nanopart Res. 15(5):1595.

Lejal N, Tarus B, Bouguyon E, Chenavas S, Bertho N, Delmas B, Ruigrok RW, Di Primo C, Slama-Schwok A.
Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus.
Antimicrobial Agents and Chemotherapy. 57(5):2231-42.

Kechaou N, Chain F, Gratadoux JJ, Blugeon S, Bertho N, Chevalier C, Le Goffic R, Courau S, Molimard P, Chatel JM, Langella P, Bermúdez-Humarán LG.
Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening. 
Appl Environ Microbiol. 79(5):1491-9.

Leymarie O, Jouvion G, Hervé PL, Chevalier C, Lorin V, Lecardonnel J, Da Costa B, Delmas B, Escriou N, Le Goffic R.
Kinetic Characterization of PB1-F2-Mediated Immunopathology during Highly Pathogenic Avian H5N1 Influenza Virus Infection.
PLoS One. 8(3):e57894. 


Loza-Rubio E, Rojas-Anaya E, Chevalier C, Rangel-Huerta E, Da Costa BDelmas B
Baculovirus system as a protein expression of influenza A/H1N1p virus.
Int J Infect Dis. 16(Suppl.1):E308.

Tarus B, Bakowiez O, Chenavas S, Duchemin L, Estrozi LF, Bourdieu C, Lejal N, Bernard J, Moudjou M, Chevalier C, Delmas B, Ruigrok RW, Di Primo C, Slama-Schwok A.
Oligomerization paths of the nucleoprotein of influenza A virus.
Biochimie. 2012, 94:776-85.

Tarus B, Chevalier C, Richard CA, Delmas B, Di Primo C, Slama-Schwok A.
Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding.
PLoS One. 2012, 7(1):e30038.

Delmas B, Mundt E, Vakharia VN, Wu JL.
Ch 045 - Family Birnaviridae. 
Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses.
Elsevier Inc. 2012

Delmas B.
Ch 050 -  Family Picobirnaviridae. 
Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses.
Elsevier Inc. 2012 


Anselmo A, Flori L, Jaffrezic F, Rutigliano T, Cecere M, Cortes-Perez N, Lefèvre F, Rogel-Gaillard C, Giuffra E.
Co-expression of host and viral microRNAs in porcine dendritic cells infected by the pseudorabies virus.
PLoS One. 6(3):e17374.

Le Goffic RLeymarie OChevalier C, Rebours E, Da Costa B, Vidic J, Descamps D, Sallenave JM, Rauch M, Samson M, Delmas B
Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2 Protein. 
PLoS Pathog. 2011 Aug;7(8):e1002202.
==> article en accès libre : http://www.plospathogens.org

Le Goffic R, Arshad MI, Rauch M, L'helgoualc'h A, Delmas B, Piquet-Pellorce C, Samson M.
Influenza Virus Infection Induces IL-33 in Mouse Lungs.
Am J Respir Cell Mol Biol. 2011 Dec;45(6):1125-32.

Delmas B, Mundt E, Gorbalenya A.
Birnavirus VP4 processing endopeptidase.
Handbook of proteases. 2011, Chapt. 812 in 3rd Edition.

Da Costa B, Duquerroy S, Tarus BDelmas B.
Picobirnaviruses encode a protein with repeats of the ExxRxNxxxE motif. 
Virus Res. 2011 Jun;158(1-2):251-6.



Le Goffic R, Bouguyon E, Chevalier C, Vidic J, Da Costa BLeymarie OBourdieu CDecamps L, Dhorne-Pollet S, Delmas B.
Influenza A virus protein PB1-F2 exacerbates IFN-beta expression of human respiratory epithelial cells.
J Immunol. 2010 Oct 15;185(8):4812-23.
==> article en accès libre :  J Immunol.

Galloux M, Libersou S, Alves ID, Marquant R, Salgado GF, Rezaei H, Lepault J, Delmas B, Bouaziz S, Morellet N. 
NMR structure of a viral peptide inserted in artificial membranes: a view on the early steps of the birnavirus entry process. 
J Biol Chem. 2010 Jun 18;285(25):19409-21.
==> article en accès libre : http://www.jbc.org

Chevalier CAl Bazzal A, Vidic J, Février V, Bourdieu C, Bouguyon E, Le Goffic R, Vautherot JF, Bernard J, Moudjou M, Noinville S, Chich JF, Da Costa B, Rezaei H, Delmas B
PB1-F2 influenza A virus protein adopts a beta-sheet conformation and forms amyloid fibers in membrane environments.
J Biol Chem. 2010 Apr 23;285(17):13233-43.
==> article en accès libre : http://www.jbc.org

Coulibaly F, Chevalier CDelmas B, Rey FA.
Crystal structure of an Aquabirnavirus particle: insights into antigenic diversity and virulence determinism. 
J Virol. 2010 Feb;84(4):1792-9.
==> article en accès libre : http://jvi.asm.org/



Duquerroy S, Da Costa B, Henry C, Vigouroux A, Libersou S, Lepault J, Navaza J, Delmas B, Rey FA. 
The picobirnavirus crystal structure provides functional insights into virion assembly and cell entry.
EMBO J. 2009 Jun 3;28(11):1655-65.
==> article en accès libre : www.embojournal.org

Rémond M, Da Costa B, Riffault S, Parida S, Breard E, Lebreton F, Zientara S, Delmas B
Infectious bursal disease subviral particles displaying the foot-and-mouth disease virus major antigenic site.
Vaccine. 2009 Jan 1;27(1):93-8.



Ben Abdeljelil N, Delmas B, Mardassi H. 
Replication and packaging of an infectious bursal disease virus segment A-derived minigenome. 
Virus Res. 2008 Sep;136(1-2):146-51.

LeBouder FMorello E, Rimmelzwaan GF, Bosse F, Péchoux C, Delmas BRiteau B.
Annexin II incorporated into influenza virus particles supports virus replication by converting plasminogen into plasmin.
J Virol. 2008 Jul;82(14):6820-8.

Nobiron I, Galloux M, Henry C, Torhy C, Boudinot P, Lejal NDa Costa BDelmas B.
Genome and polypeptides characterization of Tellina virus 1 reveals a fifth genetic cluster in the Birnaviridae family. 
Virology. 2008 Feb 20;371(2):350-61.



Letzel T, Coulibaly F, Rey FA, Delmas B, Jagt E, van Loon AA, Mundt E.

Molecular and structural bases for the antigenicity of VP2 of infectious bursal disease virus. 
J Virol. 2007 Dec;81(23):12827-35. 
Lee J, Feldman AR, Delmas B, Paetzel M. 
Crystal structure of the VP4 protease from infectious pancreatic necrosis virus reveals the acyl-enzyme complex for an intermolecular self-cleavage reaction. 
J Biol Chem. 2007 Aug 24;282(34):24928-37.
Galloux M, Libersou S, Morellet N, Bouaziz S, Da Costa B, Ouldali M, Lepault J, Delmas B.
Infectious bursal disease virus, a non-enveloped virus, possesses a capsid-associated peptide that deforms and perforates biological membranes.
J Biol Chem. 2007 Jul 13;282(28):20774-84.



Lee J, Feldman AR, Chiu E, Chan C, Kim YN, Delmas B, Paetzel M. 
Purification, crystallization and preliminary X-ray analysis of truncated and mutant forms of VP4 protease from infectious pancreatic necrosis virus.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt 12):1235-8.
Feldman AR, Lee J, Delmas B, Paetzel M. 
Crystal structure of a novel viral protease with a serine/lysine catalytic dyad mechanism. 
J Mol Biol. 2006 May 19;358(5):1378-89. 
Lee J, Feldman AR, Delmas B, Paetzel M. 
Expression, purification and crystallization of a birnavirus-encoded protease, VP4, from blotched snakehead virus (BSNV). 
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt 4):353-6.



Chevalier C, Galloux M, Pous J, Henry C, Denis J, Da Costa B, Navaza J, Lepault J, Delmas B
Structural peptides of a nonenveloped virus are involved in assembly and membrane translocation.
J Virol. 2005 Oct;79(19):12253-63. 
Pous J, Chevalier C, Ouldali M, Navaza J, Delmas B, Lepault J. 
Structure of birnavirus-like particles determined by combined electron cryomicroscopy and X-ray crystallography. 
J Gen Virol. 2005 Aug;86(Pt 8):2339-46.
Coulibaly F, Chevalier C, Gutsche I, Pous J, Navaza J, Bressanelli S, Delmas B, Rey FA.
The birnavirus crystal structure reveals structural relationships among icosahedral viruses. 
Cell. 2005 Mar 25;120(6):761-72.
Nobiron I, Rémond M, Kaiser C, Lebreton F, Zientara S, Delmas B. The
nucleotide sequence of foot-and-mouth disease virus O/FRA/1/2001 and comparison with its British parental strain O/UKG/35/2001.
Virus Res. 2005 Mar;108(1-2):225-9.



Galloux M, Chevalier C, Henry C, Huet JC, Da Costa BDelmas B.
Peptides resulting from the pVP2 C-terminal processing are present in infectious pancreatic necrosis virus particles. 
J Gen Virol. 2004 Aug;85(Pt 8):2231-6.
Francois A, Chevalier C, Delmas B, Eterradossi N, Toquin D, Rivallan G, Langlois P.
Avian adenovirus CELO recombinants expressing VP2 of infectious bursal disease virus induce protection against bursal disease in chickens.
Vaccine. 2004 Jun 2;22(17-18):2351-60.
Chevalier C, Lepault J, Da Costa BDelmas B
The last C-terminal residue of VP3, glutamic acid 257, controls capsid assembly of infectious bursal disease virus.
J Virol. 2004 Apr;78(7):3296-303. 
Da Costa B, Soignier S, Chevalier C, Henry C, Thory C, Huet JC, Delmas B.
Blotched snakehead virus is a new aquatic birnavirus that is slightly more related to avibirnavirus than to aquabirnavirus. 
J Virol. 2003 Jan;77(1):719-25. 
Da Costa BChevalier C, Henry C, Huet JC, Petit S, Lepault J, Boot H, Delmas B.
The capsid of infectious bursal disease virus contains several small peptides arising from the maturation process of pVP2. 
J Virol. 2002 Mar;76(5):2393-402.
Chevalier C, Lepault J, Erk I, Da Costa BDelmas B
The maturation process of pVP2 requires assembly of infectious bursal disease virus capsids.
J Virol. 2002 Mar;76(5):2384-92.